Pharmacodynamics
Also known as PD
What a drug does to the body — the receptor binding and downstream signalling that produce the clinical effect.
Definition
Pharmacodynamics describes the biochemical and physiological effects of a drug at its site of action — receptor affinity, selectivity, intrinsic activity, and the downstream cellular and tissue response. Together with pharmacokinetics (what the body does to the drug), PD determines the dose-response relationship.
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PharmacokineticsPK
What the body does to a drug — absorption, distribution, metabolism and excretion. The science of dose-to-plasma-level relationships.
MechanismReceptor Binding
The molecular interaction between a drug and its receptor — the first step in pharmacodynamics and the determinant of specificity.
MechanismAgonist
A molecule that binds a receptor and triggers its activity — most therapeutic peptides are agonists of a specific endogenous receptor.
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