meto
Biomarker

Free T4

Also known as Free Thyroxine

The unbound, bioavailable fraction of thyroxine — the main circulating thyroid hormone.

Definition

T4 (thyroxine) is the main thyroid hormone produced by the gland, existing mostly bound to transport proteins. Free T4 is the unbound, bioavailable fraction that tissues can use. Measured alongside TSH and free T3 to characterise thyroid status — especially useful in central hypothyroidism where TSH may be misleadingly normal.

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