HPA Axis
Also known as Hypothalamic-Pituitary-Adrenal Axis
The feedback loop between hypothalamus, pituitary and adrenals that governs cortisol and stress response.
Definition
The hypothalamic-pituitary-adrenal axis is the body's central stress-response system. It regulates cortisol release through a negative-feedback loop that's easily disrupted by exogenous hormones. Full HGH therapy suppresses the parallel hypothalamic-pituitary-somatotropic axis; GHRH analogs like CJC-1295 and Sermorelin work upstream and leave the feedback loop intact — the core safety advantage of GH-axis peptides.
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Cortisol
The body's primary stress hormone, secreted by the adrenals under HPA-axis control — one thing Ipamorelin specifically does not raise.
MechanismGrowth HormoneGH
A pituitary-secreted hormone that drives protein synthesis, fat metabolism and tissue repair — released in pulses, peaking at night.
MechanismGHRH AnalogGrowth-Hormone-Releasing Hormone Analog
A class of peptides that mimic growth-hormone-releasing hormone at the pituitary to trigger the body's own GH release — CJC-1295, Tesamorelin and Sermorelin.
$149 panel.
A clinician reads it in 24 hours.
Order the Peptide Readiness Panel, draw at a Quest or LabCorp near you, and your clinician sends back a matched protocol with a confidence score.