CJC-1295
Also known as CJC-1295 no-DAC · Modified GRF(1-29)
A GHRH analog that extends the body's natural growth-hormone pulses — typically paired with Ipamorelin for muscle preservation and sleep quality.
Definition
CJC-1295 (no-DAC variant) is a modified 30-amino-acid analog of growth-hormone-releasing hormone. It resists enzymatic degradation, extending the duration of GHRH signalling at the pituitary.
How Meto uses it.
CJC-1295 is no longer part of the Meto catalogue and is not prescribed in any current protocol — the P2 Muscle Preservation Stack now uses sermorelin acetate as its GHRH analog.
Safety notes
- Contraindicated in active malignancy and GH-sensitive tumour history
- Contraindicated in type-1 diabetes and uncontrolled type-2 diabetes
- Avoid in active retinopathy and severe carpal tunnel
- Not for use in pregnancy, lactation, or women planning pregnancy
- IGF-1 is the biomarker monitored at month 3 and month 6 to confirm target range
Not a complete list — your clinician reviews your full history, labs and medications during intake. Nothing here replaces that.
Common questions
CJC-1295 vs. HGH — what's the real difference?
HGH floods the system with exogenous growth hormone and shuts down the pituitary's own output. CJC-1295 asks the pituitary to release more of its own GH — smaller peaks, preserved negative-feedback loop, fewer side effects, and a clean exit when you stop.
Why is it paired with Ipamorelin?
CJC-1295 extends GHRH signalling; Ipamorelin triggers pulsatile GH release via the ghrelin receptor. Together they recreate the natural pulsatile rhythm that declines with age. Either one alone produces a weaker, less physiological signal.
Will this make me retain water or grow organs?
At the doses studied — 100–300 mcg nightly — IGF-1 stays within the upper half of age-adjusted range, which avoids the oedema and acromegalic effects associated with supraphysiological HGH. On any GH-axis protocol, your clinician re-checks IGF-1 at month 3 and 6 specifically to catch overshoot.
Is the DAC version different?
Yes. CJC-1295-with-DAC binds serum albumin and produces a continuous 'GH bleed' over days, which is less physiological and harder to titrate. Where the no-DAC variant is used, it's chosen specifically to preserve pulsatility.
Read More
GHRH AnalogGrowth-Hormone-Releasing Hormone Analog
A class of peptides that mimic growth-hormone-releasing hormone at the pituitary to trigger the body's own GH release — CJC-1295, Tesamorelin and Sermorelin.
PeptideSermorelin
A native GHRH analog — the gentlest and most-studied entry point into growth-hormone-axis therapy.
MechanismGrowth HormoneGH
A pituitary-secreted hormone that drives protein synthesis, fat metabolism and tissue repair — released in pulses, peaking at night.
$149 panel.
A clinician reads it in 24 hours.
Order the Peptide Readiness Panel, draw at a Quest or LabCorp near you, and your clinician sends back a matched protocol with a confidence score.