Sermorelin
A native GHRH analog — the gentlest and most-studied entry point into growth-hormone-axis therapy.
Definition
A 29-amino-acid peptide matching the initial 29 residues of human growth-hormone-releasing hormone. It binds the GHRH receptor in the pituitary, triggering endogenous GH release while maintaining the negative-feedback loop. Described as shorter-acting than modified GHRH analogs with a cleaner regulatory history.
How Meto uses it.
Part of Meto's P2 Muscle Preservation Stack. Also prescribed solo for members preferring a gentler entry. Dosing: nightly subcutaneous on a 5-on / 2-off schedule, typically in 3–6 month cycles with IGF-1 re-checked at month 3. Noted as "the most regulatorily uncomplicated peptide in the GH-axis family."
Safety notes
- Contraindicated in active malignancy
- Reduced effectiveness in severe obesity
- Not for use in pregnancy or lactation
- Injection-site redness is the most common report
Not a complete list — your clinician reviews your full history, labs and medications during intake. Nothing here replaces that.
Common questions
Sermorelin vs. Tesamorelin — which should I choose?
Sermorelin offers smaller, tighter GH pulses — the gentler entry point; Tesamorelin is indicated when visceral-fat reduction is the specific goal.
Do I still need labs for Sermorelin?
Yes; IGF-1 at baseline and month 3 are the minimum.
Read More
GHRH AnalogGrowth-Hormone-Releasing Hormone Analog
A class of peptides that mimic growth-hormone-releasing hormone at the pituitary to trigger the body's own GH release — CJC-1295, Tesamorelin and Sermorelin.
PeptideTesamorelin
A stabilised GHRH analog with FDA approval for visceral-fat reduction in HIV-associated lipodystrophy — increasingly used off-label for metabolic syndrome.
MechanismGrowth HormoneGH
A pituitary-secreted hormone that drives protein synthesis, fat metabolism and tissue repair — released in pulses, peaking at night.
$149 panel.
A clinician reads it in 24 hours.
Order the Peptide Readiness Panel, draw at a Quest or LabCorp near you, and your clinician sends back a matched protocol with a confidence score.