SHBG
Also known as Sex Hormone-Binding Globulin
A hepatic protein that binds testosterone and estradiol — affects how much hormone is bioavailable and how lab values are interpreted.
Definition
SHBG is produced by the liver and binds sex hormones in blood, regulating their bioavailability. Low SHBG is associated with metabolic syndrome and insulin resistance; high SHBG is associated with hyperthyroidism and certain hepatic conditions. Correct interpretation of total testosterone requires knowing SHBG — the same total value can reflect very different free-hormone activity depending on SHBG.
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Testosterone
The primary male androgen — measured as total and free fractions. Low levels in men drive the TRT decision; in women, context is everything.
BiomarkerBiomarker
A measurable substance in blood, tissue or urine that reflects a biological state — the inputs your clinician uses to choose the right protocol.
Clinical ConceptMetabolic Syndrome
A cluster of five conditions — central obesity, hypertension, dyslipidaemia, hyperglycaemia, low HDL — that together multiply cardiovascular risk.
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