meto
Mechanism

Ghrelin

The 'hunger hormone' secreted by the stomach — its receptor is the target of GH secretagogues like Ipamorelin.

Definition

Ghrelin is a 28-amino-acid peptide produced mainly by the stomach that stimulates appetite and, separately, growth-hormone release via the GHS-R1a receptor at the pituitary. Ipamorelin and related GH secretagogues exploit the latter pathway without activating the appetite side. Understanding this two-axis receptor is why GH secretagogues don't cause the weight-gain effects people sometimes expect.

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