Ipamorelin
A selective growth-hormone secretagogue that triggers GH release without spiking cortisol or prolactin — usually paired with CJC-1295.
Definition
Ipamorelin is a five-amino-acid peptide that activates the ghrelin (GHS-R1a) receptor at the pituitary, triggering pulsatile growth-hormone release. Older GH secretagogues elevated cortisol, prolactin and ACTH; Ipamorelin does not. Clinical application typically involves combining it with a GHRH analog like CJC-1295 to recreate a youthful, pulsatile GH rhythm.
How Meto uses it.
Ipamorelin is no longer part of the Meto catalogue and is not prescribed in any current protocol — the P2 Muscle Preservation Stack now uses sermorelin acetate. The entry exists as a reference definition for readers researching the molecule.
Safety notes
- Contraindicated in active malignancy and GH-sensitive tumor history
- Contraindicated in type-1 diabetes and uncontrolled type-2 diabetes
- Not for use in pregnancy or lactation
- No measurable effect on cortisol or prolactin — that's the point versus older secretagogues
- Transient appetite increase is possible...but rarely clinically meaningful
Not a complete list — your clinician reviews your full history, labs and medications during intake. Nothing here replaces that.
Common questions
Will Ipamorelin make me hungry?
At the doses used (100–300 mcg nightly), most members notice no meaningful shift; some report a mild morning-appetite bump that's easily managed.
Why pair it with CJC-1295?
The combination recreates the natural pulsatile rhythm, which declines with age. Either alone is a weaker clinical signal.
Can I use Ipamorelin during weight loss?
Ipamorelin itself isn't something Meto prescribes. Members over 40 on semaglutide or tirzepatide are prescribed P2 — a sermorelin protocol — for that goal.
Read More
Growth HormoneGH
A pituitary-secreted hormone that drives protein synthesis, fat metabolism and tissue repair — released in pulses, peaking at night.
MechanismGhrelin
The 'hunger hormone' secreted by the stomach — its receptor is the target of GH secretagogues like Ipamorelin.
PeptideSermorelin
A native GHRH analog — the gentlest and most-studied entry point into growth-hormone-axis therapy.
$149 panel.
A clinician reads it in 24 hours.
Order the Peptide Readiness Panel, draw at a Quest or LabCorp near you, and your clinician sends back a matched protocol with a confidence score.