Somatostatin
A hypothalamic peptide that inhibits growth-hormone release — the brake that balances the GHRH accelerator.
Definition
Somatostatin is a 14-amino-acid peptide released by the hypothalamus that inhibits GH release from the pituitary. It's the counterweight to GHRH in regulating the pulsatile GH rhythm: GHRH drives release, somatostatin silences it between pulses. Understanding this balance is why GH-axis peptide protocols preserve pulsatility — continuous GHRH-like stimulation elevates somatostatin in compensation.
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Growth HormoneGH
A pituitary-secreted hormone that drives protein synthesis, fat metabolism and tissue repair — released in pulses, peaking at night.
MechanismGHRH AnalogGrowth-Hormone-Releasing Hormone Analog
A class of peptides that mimic growth-hormone-releasing hormone at the pituitary to trigger the body's own GH release — CJC-1295, Tesamorelin and Sermorelin.
Clinical ConceptPituitary Gland
The 'master gland' at the base of the brain that secretes growth hormone, ACTH, TSH and other downstream hormones.
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