Fasting for a Longer Life: The Best Method for Health, Weight Loss & Longevity
By Dr. Priyali S.
Reviewed by Dr. Jossy Onwude
Published Apr 11, 2025
Updated Apr 15, 2025
9 min read

Fasting might sound like a trendy health craze, but it’s actually been around for thousands of years. People have fasted for spiritual reasons, for mental clarity, or simply because food wasn’t always available. Today, fasting is gaining serious attention from scientists and health experts—not just as a tool for weight loss, but as a powerful way to support overall health and even help us live longer.
But with so many types of fasting out there—16:8, OMAD, alternate-day fasting, the 5:2 method—it can feel overwhelming to figure out which one is right for you. If you’ve ever wondered, “Which fasting method is actually the best for health, longevity, and weight loss?”—you’re in the right place.
Let’s break it all down in plain English.
What Is Fasting, Really?
At its core, fasting simply means not eating for a certain period of time. That’s it. It’s not about starving yourself, and it’s not about punishing your body. It’s about giving your body a break from constant digestion so it can do some important “housekeeping” work.
When you fast, your body stops using energy to process food and shifts into a different mode—one that can help repair cells, burn fat, and regulate important hormones. This change is natural. In fact, our ancestors fasted regularly without even realizing it. They didn’t have snacks available 24/7. They ate when food was around and fasted when it wasn’t.
Fasting is also different from a diet. It doesn’t tell you what to eat, but rather when to eat. That’s a huge part of what makes it so flexible and popular.
Why Fasting Works: The Science (Made Simple)
When you eat, especially foods high in sugar or carbs, your body releases insulin. Insulin helps move sugar from your blood into your cells so it can be used for energy. But when you’re constantly eating—especially snacking throughout the day—your insulin levels stay high. That makes it harder for your body to burn fat.
When you fast, your insulin levels drop. That signals your body to start burning stored fat for energy. Even more interestingly, fasting triggers a process called autophagy, which is like your body’s own spring-cleaning system. Old or damaged cells get broken down and recycled. This is believed to be one of the ways fasting supports longevity and reduces the risk of diseases.
Scientists have also found that fasting can improve metabolism, reduce inflammation, and support brain health. And no, you don’t need to fast for days on end to see benefits. Even short fasting periods can make a difference.
The Most Popular Fasting Methods (And How They Work)
Let’s look at the most common types of fasting people are using today. Each one works a bit differently, and some are easier to stick with than others.
1. Time-Restricted Eating (TRE) – Example: 16:8
This is probably the most popular form of fasting. You fast for 16 hours and eat all your meals within an 8-hour window. So, for example, you might eat between 12 PM and 8 PM, and fast from 8 PM to 12 PM the next day.
It’s simple, flexible, and easy to fit into your daily routine. Most people naturally fast overnight anyway, so it’s not a huge jump.
2. Alternate-Day Fasting (ADF)
With this method, you fast every other day. On fasting days, some people eat nothing, while others eat very little (about 500 calories). On non-fasting days, you eat normally.
This method can be intense and isn’t for everyone, but some studies suggest it’s very effective for weight loss.
3. 5:2 Diet
Here, you eat normally for five days of the week and restrict your calories to about 500–600 on the other two days (they don’t have to be consecutive).
This method is less restrictive and can be a good starting point for beginners who want to ease into fasting.
4. OMAD – One Meal A Day
This is exactly what it sounds like. You eat one big meal each day and fast the rest of the time. OMAD can lead to quick weight loss, but it’s also hard to sustain for most people and may not provide enough nutrients unless carefully planned.
5. Prolonged Fasting (24–72 Hours)
Some people do longer fasts occasionally, such as 24, 48, or even 72 hours. These fasts are usually done under supervision or by experienced fasters. They may support deep cellular repair but aren’t necessary for everyday benefits.
6. Fasting Mimicking Diet (FMD)
FMD isn’t true fasting, but it’s designed to mimic the effects of fasting while still allowing you to eat small amounts of specific foods. It’s usually done for 5 days and has been studied for its effects on aging and disease prevention.
The Best Fasting Method for Longevity

When it comes to living longer, the research points to a few key processes: lowering inflammation, improving cellular repair, and maintaining healthy blood sugar and insulin levels. Fasting supports all of these, but some methods do it better than others.
One of the most promising fasting strategies for longevity is Time-Restricted Eating (TRE). It’s easy to stick with long-term and encourages consistent fasting periods each day, which helps your body get into a rhythm. Studies show that people who eat within a consistent 6–10 hour window each day have lower risks of chronic diseases and may age more gracefully.
Another great option is the Fasting Mimicking Diet (FMD). Created by Dr. Valter Longo, this 5-day diet plan tricks your body into thinking it's fasting, even though you're eating small amounts of food. Research shows FMD can promote stem cell regeneration and reduce risk factors for aging and disease.
So, if longevity is your goal, start with daily time-restricted eating and consider doing a Fasting Mimicking Diet every few months under guidance.
The Best Fasting Method for Weight Loss
Losing weight comes down to one simple idea: burning more energy than you consume. Fasting helps by naturally reducing how much you eat, especially if you're skipping breakfast or late-night snacks. But some methods work better than others.
- Alternate-Day Fasting (ADF) tends to produce quick weight loss results because it creates big calorie deficits. But it’s tough to maintain.
- OMAD also leads to fast weight loss, but it may be too extreme for some and can lead to binge eating.
- 16:8 Time-Restricted Eating, however, strikes a nice balance. It helps people naturally eat less without feeling deprived, and it’s easier to maintain than more extreme fasts. Over time, 16:8 can lead to steady fat loss and improved body composition—especially when combined with a healthy diet.
So if weight loss is your goal, start with 16:8. It’s gentle, effective, and fits into almost any lifestyle.
The Best Fasting Method for Overall Health
Fasting doesn’t just help with weight and aging—it supports heart health, brain function, and even mental clarity.
People who fast regularly often see improvements in:
- Blood pressure
- Blood sugar levels
- Cholesterol
- Inflammation markers
- Focus and energy
Among all fasting types, Time-Restricted Eating (TRE) continues to shine. Studies show it helps regulate the body’s circadian rhythm—the internal clock that controls sleep, metabolism, and hormone release. When your eating is in sync with your body’s natural clock, everything just works better.
Fasting Mimicking Diet also shows great promise for disease prevention, especially in people with prediabetes, high blood pressure, or family history of chronic illness.
If your main goal is better health overall, TRE is the most realistic and sustainable place to start.
How to Choose the Right Fasting Method for You

There’s no one-size-fits-all fasting method. The best approach is the one you can stick with over the long term.
Here are a few things to consider:
- If you’re new to fasting, start slow. Try 12 hours of fasting first (like 8 PM to 8 AM), then build up to 14 or 16 hours.
- If you have a busy schedule, 16:8 works great.
- If you enjoy routines, OMAD or 5:2 might appeal to you.
- If you have medical conditions, always talk to your doctor before starting any fasting plan.
Remember, fasting doesn’t replace healthy eating. It works best when combined with whole foods, fruits and vegetables, lean proteins, healthy fats, and good hydration.
Common Mistakes to Avoid
It’s easy to get excited about fasting and overdo it. Here are a few things to watch out for:
- Not drinking enough water: Fasting can be dehydrating. Drink lots of water, and consider adding electrolytes.
- Overeating during the eating window: It’s tempting to eat everything in sight after a fast. Try to eat normally and mindfully.
- Fasting too aggressively too soon: Start slow. Going straight into a 24-hour fast can shock your system.
- Skipping nutrients: Even while fasting, make sure your meals include a mix of protein, fiber, and healthy fats.
Pro Tips for Fasting Success
Here are a few things that make fasting easier and more enjoyable:
- Drink water, black coffee, or tea during your fasting window. These don’t break your fast and can help with hunger.
- Keep busy. You’re more likely to feel hungry when you’re bored.
- Plan your meals ahead of time so you’re not reaching for junk food when your eating window opens.
- Get enough sleep. Poor sleep makes fasting harder and increases cravings.
Frequently Asked Questions
1. Can I drink coffee while fasting?
Yes! Black coffee is fine. Just don’t add sugar or cream.
2. Does fasting slow down metabolism?
Not when done properly. In fact, short-term fasting can actually boost metabolism. Long-term, very low-calorie diets are what slow it down.
3. What breaks a fast?
Anything with calories technically breaks a fast. But many people allow black coffee, tea, or a splash of lemon in water.
4. Is fasting safe for teens or young people?
Fasting isn’t usually recommended for kids or teens unless under medical supervision. Growing bodies need regular nutrition. Focus on healthy eating habits first.
So, What’s the Best Fasting Method?
If you’re looking for a method that supports weight loss, better health, and possibly a longer life, 16:8 Time-Restricted Eating is your best bet. It’s flexible, simple, and easy to stick with.
For deeper cellular benefits or chronic disease prevention, Fasting Mimicking Diet cycles a few times a year can be added for extra impact.
But above all, the best fasting method is the one that fits your life, makes you feel good, and is something you can do consistently. Fasting isn’t a quick fix—it’s a tool. And when used wisely, it can be one of the simplest and most powerful ways to take control of your health.
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