Lose Weight—Safely and Gradually—with Topiramate
Topiramate is a prescription medication primarily used to:
Prevent and control seizures (as an anticonvulsant).
Prevent migraine headaches (not for treating a migraine that has already started).
It works by calming overactive nerve activity in the brain. It may also be prescribed off-label for weight loss, bipolar disorder, or alcohol dependence.
- Balances blood sugar
- Same active ingredient in Wegovy® and Ozempic®.
- Personalized weight loss plans from meto’s licensed experts
Everything you need to know about Injectable compounded Topiramate
What is Topiramate
Topiramate is an oral anticonvulsant that also curbs appetite and cravings. When combined with calorie control and increased activity, it promotes steady, meaningful weight loss.
Randomized trials show average reductions of roughly five to six percent of starting body weight within six months at daily doses between 64 mg and 384 mg, with weight still trending downward at the study’s end.
Originally approved to treat epilepsy and prevent migraines, topiramate is now widely prescribed “off-label” as a long-term aid for adults with obesity or overweight. Its appetite-suppressing and craving-reducing effects make it a useful option in comprehensive weight-management plans.
What is Topiramate
In the pivotal six-month study, participants taking 192 mg or 384 mg daily lost about 6.3 percent of their body weight, while those on 64 mg or 96 mg lost around five percent.
The placebo group lost only 2.6 percent. Because weight had not plateaued by six months, longer use often yields additional loss—especially when paired with dietary coaching and regular exercise..
Is Topiramate safe and effective for weight loss?
Topiramate calms overactive nerve signaling through several mechanisms: it enhances GABA-A inhibition, blocks voltage-gated sodium channels, dampens AMPA-type glutamate transmission, and mildly inhibits carbonic anhydrase. Together these actions temper reward circuits linked to food, lessen hunger signals, and may slightly raise energy expenditure.
Generic topiramate is inexpensive. In April 2025 a 30-day supply of 200 mg (60 × 100 mg tablets) averages about $155 at U.S. retail pharmacies, but large-chain discount programs and coupon services can drop the price to well under $10. Sprinkle and extended-release capsules cost a bit more.
Alternative medication
