Lose Weight with Naltrexone-Bupropion
Naltrexone-Bupropion is a combination medication used to support weight loss in adults with obesity or weight-related health issues. It works by reducing appetite and cravings while also affecting brain pathways involved in hunger and reward.
- Balances blood sugar
- Same active ingredient in Wegovy® and Ozempic®.
- Personalized weight loss plans from meto’s licensed experts
Everything you need to know about Injectable compounded Naltrexone-Bupropion
What is Naltrexone-Bupropion
Naltrexone-bupropion is an FDA-approved medication prescribed for weight loss. It is a combination of two drugs, naltrexone and bupropion.
Naltrexone is an opioid receptor antagonist and is commonly used to treat opioid addiction and alcohol dependence. Bupropion is an antidepressant that also aids in smoking cessation.
The combination of these two medications in Naltrexone-Bupropion helps target different aspects of weight management, making it an effective option for weight loss.
Is Naltrexone-Bupropion Safe and Effective for Weight Loss?
Naltrexone-bupropion has been proven in clinical trials to be effective in aiding weight loss. In a 56-week study, individuals who used naltrexone-bupropion along with lifestyle modifications experienced an average weight loss of 8.1 kilograms (about 9% of their initial body weight) compared to those who took a placebo.
The medication benefits both weight loss and maintaining weight loss when taken as part of a comprehensive weight management plan that includes lifestyle modifications and behavioral therapy. However, it is important to note that individual results may vary, and weight loss cannot be guaranteed.
How Does Naltrexone-Bupropion Work?
Naltrexone and bupropion have different mechanisms of action that contribute to weight loss. Naltrexone blocks opioid receptors in the hypothalamus, reducing the pleasurable feelings and cravings associated with food. Bupropion, on the other hand, enhances the activity of certain neurotransmitters in the brain, including dopamine and norepinephrine, which suppress appetite and increase energy expenditure.
The cost of naltrexone-bupropion can vary depending on factors such as insurance coverage and whether you choose the brand name medication or generic options. The brand name Contrave can be expensive, with an estimated cost of up to $300 for a 30-day supply. Generic versions of naltrexone-bupropion are more affordable, typically costing around $40 for a 30-day supply.
Alternative medication
Individuals who cannot use naltrexone-bupropion due to contraindications or have not achieved satisfactory weight loss may consider alternative weight-loss medications such as;
