Meto vs. Success by Sesame: Which Metabolic Health Platform is Right for You?

Success by Sesame is the weight loss and metabolic health program created by Sesame, a direct-to-patient healthcare marketplace. It offers GLP-1 prescriptions (like Wegovy and Ozempic) to eligible patients, bundled with virtual doctor visits, ongoing check-ins, and medication delivery. The program is designed to be affordable and accessible, targeting individuals who want quick access to GLP-1 medications without going through traditional health systems. While it includes lifestyle tips and some coaching support, its main value proposition is fast, convenient access to prescription medications, at a lower cash price than many competitors.

Meto, by contrast, is a doctor-led metabolic health platform that treats weight as a medical, hormonal, and behavioral issue — not just a number on the scale. Rather than focusing solely on GLP-1s, Meto combines clinical diagnostics, prescription support, personalized care plans, and AI-powered monitoring tools to guide long-term metabolic health. It’s built for people navigating complex conditions like insulin resistance, PCOS, or midlife metabolic decline. Unlike Sesame’s cash-only model, Meto works with most major insurance providers, offering a broader, more comprehensive path to health that's as focused on deprescribing and sustainability as it is on access.

Features	Meto	Success by Sesame
Approach to Care	Medical-led, personalized metabolic and hormonal health care.	Fast-track prescription access for GLP-1s with basic coaching.
Use of Technology	AI-powered clinical insights, integrated telehealth, device and lab integrations.	Video visits and app messaging; no biometric integrations.
Insurance Coverage	Accepts most major insurance providers.	Cash-pay only; insurance not accepted.
Pricing Model	Copay-based, transparent pricing model.	Monthly out-of-pocket subscription with bundled medication.
Clinical Team Availability	Physicians, metabolic specialists, dietitians, and coaches.	Virtual providers for prescriptions; limited care team integration.
Availability	U.S.-focused, expanding across states.	Available in most U.S. states; pending GLP-1 supply.
Program Flexibility	Fully personalized medical plans adjusted to metabolic needs.	Medication-focused care; limited flexibility outside prescriptions.
Patient Support	Dedicated care team with continuous oversight.	Basic support via messaging; no comprehensive care plan.
Mobile & Web Experience	Web and app with health dashboards and clinical integration.	Mobile-friendly interface for scheduling and messaging.
Community and Peer Support	Small, clinician-led community and expert content.	No formal peer support or community integration.

Success by Sesame is built on convenience and simplicity: patients fill out a quick form, attend a telehealth visit, and — if eligible — begin GLP-1 treatment with minimal delays. The program focuses on reducing barriers to prescription medications and prioritizes medication access over broader lifestyle change. While it includes general guidance on nutrition and exercise, it doesn’t offer structured coaching, personalized diagnostics, or a long-term clinical care model. This makes it appealing to people who already know they want medication and aren’t seeking in-depth support or medical evaluation beyond prescription eligibility.

Meto is grounded in the idea that weight and metabolic dysfunction are rooted in biology, not willpower. It moves beyond quick fixes to offer a sustainable, medically supervised path to long-term health. The platform treats the whole person — analyzing hormonal markers, behavioral patterns, and lab results — to guide a care plan that evolves with the patient. GLP-1s may be part of the process, but they’re never the whole solution. Instead, Meto empowers people to restore balance and build lasting habits with the help of a multidisciplinary team, ongoing data tracking, and real-time medical support.

Success by Sesame connects users with licensed clinicians who evaluate them for GLP-1 prescriptions via telehealth visits. The interaction is efficient and focused almost entirely on determining eligibility for medication. While Sesame does offer follow-up visits and medication management support, these services are limited in scope and frequency. The medical team is generally not involved in broader metabolic assessment, nor does the platform offer ongoing lifestyle coaching, lab testing, or condition-specific protocols. The relationship is primarily transactional: qualify, prescribe, ship.

Meto, in contrast, is built around continuous medical care. Every patient begins with a full intake, including labs, metabolic screening, and a medical consult. Care is delivered by a coordinated team — including physicians, coaches, and specialists — and evolves based on regular feedback loops, including symptom updates, lab trends, and wearable data. Meto’s clinical model goes beyond prescription to address why someone gained weight in the first place and how to reverse it sustainably. It’s holistic, responsive, and deeply rooted in evidence-based medicine, with ongoing patient-provider engagement throughout the journey.

Personalization is one of the clearest dividing lines between these two platforms. Success by Sesame offers a relatively uniform experience: if you're eligible, you get a prescription. Some lifestyle guidance is provided, but it’s not tailored to your lab results, hormonal profile, or medical history beyond basic screening. Adjustments to your care are typically reactive (e.g., side effects or dosage questions) and not based on proactive health optimization or individual variability.

Meto, on the other hand, is built on personalization. Care plans are informed by deep clinical intake, regular lab work, biometric data from wearables, and evolving goals. Whether you're navigating PCOS, insulin resistance, or perimenopause, your protocol is uniquely designed to address your body’s specific needs. The platform continuously adapts based on your response, symptoms, and outcomes — giving you a far more precise and effective path to success than any one-size-fits-all medication program.

Both platforms offer access to GLP-1s, but the role these medications play — and how they're supported — differs significantly. Success by Sesame puts medication access at the center of its offering. It provides a streamlined process to connect with clinicians, get approved, and begin GLP-1 treatment. This approach is ideal for individuals who know they want a GLP-1 and are comfortable managing their progress largely on their own, with limited guidance from the provider.

Meto takes a more integrated medical approach. GLP-1s are only offered when clinically appropriate, and their use is embedded in a broader strategy that includes nutrition, behavior change, hormonal support, and deprescription planning. The platform monitors side effects, dosage adjustments, and progress in real-time, ensuring that the medication is working with — not against — your body. For patients concerned about long-term safety, dependence, or optimization, Meto provides a higher-touch and more clinically rigorous path.

If you’re looking for fast access to GLP-1 medications without engaging in an in-depth medical program, Success by Sesame may be a fit. It’s ideal for people who are price-conscious, don’t have insurance coverage, and prefer a light-touch approach focused on prescriptions. It’s also a good option for those who’ve already decided on GLP-1s and simply want the most affordable, frictionless path to getting started.

Meto is a better choice for individuals seeking root-cause healing, not just symptom management. It’s ideal if you’re struggling with metabolic conditions like PCOS, prediabetes, insulin resistance, or hormonal shifts, and want doctor-led care with ongoing accountability. If you value personalization, medical oversight, and long-term results over speed, Meto gives you the depth of care, data, and expertise needed to transform your metabolic health — for good.