meto
Mechanism

Amylin

A pancreatic peptide co-secreted with insulin that slows gastric emptying and reduces glucagon

Definition

Amylin is a 37-amino-acid peptide co-secreted with insulin by pancreatic β-cells. It slows gastric emptying, reduces glucagon, and promotes satiety. Pramlintide is the FDA-approved synthetic amylin analog for type-1 diabetes. Cagrilintide — a longer-acting analog being developed alongside semaglutide as CagriSema — is the next-generation addition to the incretin-adjacent weight-management pipeline.

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