DSIP
Also known as Delta Sleep-Inducing Peptide
A nine-amino-acid peptide studied for sleep architecture, particularly for deep (delta-wave) sleep restoration.
Definition
DSIP is a small peptide originally isolated from rabbit brain during slow-wave sleep research. It modulates hypothalamic signalling and, in multiple small studies, improved sleep architecture — particularly slow-wave (delta) sleep — in adults with disrupted sleep.
How Meto uses it.
Meto evaluates DSIP for protocols addressing blunted deep sleep, using subcutaneous, 100–200 mcg at bedtime, in cycles rather than continuous use.
Safety notes
- Small evidence base
- Good tolerability
- Avoid in pregnancy/lactation
- Not recommended to combine with sedatives without clinician guidance
Not a complete list — your clinician reviews your full history, labs and medications during intake. Nothing here replaces that.
Common questions
How does DSIP compare to melatonin?
They're complementary rather than competitive; some members use both — melatonin manages timing while DSIP targets deep sleep.
Is the research base strong?
The research base is small. European trials suggest benefit but modern RCTs are lacking.
Read More
Circadian Rhythm
The body's ~24-hour biological clock that governs sleep, hormone release and cellular repair
Clinical ConceptMelatonin
The hormone secreted by the pineal gland at night that regulates sleep-wake timing — downstream of circadian-active peptides.
PeptideEpitalonEpithalon
A four-amino-acid peptide that upregulates telomerase activity and restores pineal circadian signalling — typically cycled 10 days, quarterly.
$149 panel.
A clinician reads it in 24 hours.
Order the Peptide Readiness Panel, draw at a Quest or LabCorp near you, and your clinician sends back a matched protocol with a confidence score.