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Biomarker

Estradiol

Also known as E2

The primary circulating estrogen — central to reproductive, bone, cardiovascular and cognitive health in both sexes.

Definition

Estradiol is the main estrogen produced by the ovaries in premenopausal women and by aromatisation of testosterone in men and postmenopausal women. It regulates reproductive function and has broad effects on bone density, cardiovascular function and cognition. Interpretation requires context — cycle phase in premenopausal women, hormone-therapy status in menopause, ratio to testosterone in men.

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