Leptin
A hormone secreted by fat cells that signals energy stores to the brain — dysfunctional in most obesity and blunted by chronic inflammation.
Definition
Leptin is secreted by adipocytes in proportion to fat mass and acts at the hypothalamus to reduce appetite and increase energy expenditure. In obesity, central leptin signalling becomes blunted — 'leptin resistance' — such that high leptin levels fail to curb appetite. GLP-1 receptor agonists and weight loss itself partially restore leptin sensitivity.
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Leptin Resistance
The state in which elevated leptin levels fail to suppress appetite — a core mechanism of obesity and metabolic syndrome.
Clinical ConceptAdipose Tissue
Fat tissue — composed of adipocytes storing triglycerides, plus immune and vascular cells — the target of lipolytic peptides.
PeptideGLP-1 Receptor AgonistGLP-1 RA
A peptide drug class that mimics glucagon-like peptide-1 to slow gastric emptying, sharpen insulin response and quiet food-noise.
$149 panel.
A clinician reads it in 24 hours.
Order the Peptide Readiness Panel, draw at a Quest or LabCorp near you, and your clinician sends back a matched protocol with a confidence score.