Lipolysis
The biological breakdown of stored fat into free fatty acids — the mechanism targeted by AOD-9604 and Tesamorelin.
Definition
Lipolysis is the enzymatic hydrolysis of triglycerides stored in adipocytes into glycerol and free fatty acids for metabolic use. Hormones like adrenaline, glucagon and growth hormone are pro-lipolytic; insulin is anti-lipolytic. Peptides in the fat-metabolism class (AOD-9604, Tesamorelin) drive lipolysis without triggering the insulin-resistance or glucose effects of full GH.
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AOD-9604AOD9604
A modified fragment of human growth hormone (amino acids 177–191) that stimulates fat metabolism without affecting blood glucose or IGF-1.
PeptideTesamorelin
A stabilised GHRH analog with FDA approval for visceral-fat reduction in HIV-associated lipodystrophy — increasingly used off-label for metabolic syndrome.
Mechanismβ3-AdrenoceptorBeta-3 Adrenergic Receptor
A receptor on fat cells whose activation triggers lipolysis — the target of peptides like AOD-9604.
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