Clinical protocols, member stories, and plain-language science from the Meto care team. We publish what we'd want to read if we were figuring this out for the first time

Peptide stacking has become increasingly popular in metabolic health and biohacking circles—but most combinations are poorly understood. This evidence-based guide explains when stacking peptides may make biological sense, when it doesn’t, and how clinics evaluate safety, mechanisms, and outcomes before combining therapies.

AOD-9604 is a synthetic peptide derived from the 176–191 fragment of human growth hormone. It was developed to stimulate fat breakdown (lipolysis) without increasing growth hormone or IGF-1 levels. While clinical trials showed modest fat-loss effects, it does not produce the level of weight loss seen with modern GLP-1 medications like semaglutide or tirzepatide.